Research projects
We are involved in publicly funded projects
R&D Projects
European Projects
EIC Pathfinders
2023 – 2027
MEDICAL DEVICES
A Paradigm Shift in Health Monitoring with Electrospun Enzymatic Neomaterials
Woundsens
The WOUNDSENS project addresses the global healthcare challenge posed by chronic non-healing wounds, affecting up to 2% of the world population. Recognizing the lack of smart bandages in the market, the project aims to pioneer a novel generation of wearable biosensors. WOUNDSENS integrates sensor elements directly into wound dressing material, enhancing comfort and operability. This breakthrough technology utilizes hollow fibers with radial bio-signaling based on engineered enzymes. The project encompasses advances in conductive materials, electrospinning methodologies, and enzyme engineering to create a sensitive and reliable continuous wound control and monitoring system. WOUNDSENS represents a paradigm shift in smart wound dressings, offering a new concept to improve the quality of life for millions of people while addressing the economic impact on healthcare.
PERIOD: November 2023 – November 2027
TOTAL BUDGET: 2,934,318.75€
PARTNERS
- EvoEnzyme SL (Coordinator)
- Naturwissenschaftliches und medizinisches institut an der universitaet Tuebingen
- Universite de Lorraine
EXTENDED CONSORTIUM MEMBERS
- Institut Jean Lamour (IJL): Joint Research Unit of Université de Lorraine (UL) and the Centre National de la Recherche Scientifique (CNRS) (Affiliated Entity)
EVOENZYME PARTICIPATION
EvoEnzyme functions as the Coordinator of the WOUNDSENS project. Additionally, our role involves working on enzyme engineering for sensor manufacturing through directed evolution and computational methods.
Learn more about the project through its videos and podcasts by visiting the WoundSens YouTube channel.
Latest news
- June 25, 2025
- June 20, 2025
2024-2028
SUSTAINABLE CHEMISTRY
Tungsten biocatalysis – heavy metal enzymes for sustainable industrial biocatalysis
W-BioCat
The W-BioCat project addresses the need for a sustainable chemical industry in Europe through groundbreaking enzyme technology. By unlocking the potential of tungsten-containing enzymes (W-enzymes), the project aims to revolutionize chemical manufacturing. Focusing on overcoming the bottleneck of W-cofactor biosynthesis in E. coli, the project utilizes advanced computational enzyme design to create a new biosynthesis pathway. This innovation will enable the production of W-enzymes at an industrial scale, paving the way for their application in catalyzing novel chemical reactions, including biocatalytic CO2 reduction and Birch reduction of aromatic compounds. W-BioCat’s proof of concept involves a hydrogen-driven process to convert plant-derived oleic acid to oleyl oleate, a key ingredient in cosmetic products.
PERIOD: February 2024 – February 2028
TOTAL BUDGET: 2,430,574.75€
PARTNERS
- TU Delft (Coordinator)
- EvoEnzyme SL
- Weizmann institute of science
- Consorzio interuniversitario risonanze magnetiche di metallo proteine
- Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences (IKIFP PAN)
EVOENZYME PARTICIPATION
EvoEnzyme will play a crucial role in the W-BioCat project, focusing on protein engineering through ancestral reconstruction, resurrection, and directed evolution of W-enzymes. Our expertise in these advanced techniques will contribute to the successful development and optimization of novel W-enzyme systems.
Latest news
Other European projects
2025 – 2029
PLASTIC DEGRADATION
Bio-based in Soil applications with Optimal biodegradation in their Ultimate Life
SOUL
Call: HORIZON-JU-CBE-2024-IA-01
The SOUL project addresses the environmental impact in soils of plastic pollution and waste. Plastic products — extensively used in construction, agriculture, and packaging — are largely unrecyclable, frequently mismanaged after use, and contribute significantly to soil contamination, microplastic accumulation, and greenhouse gas emissions. This ultimately impairs soil health and fertility, and leads to human health hazards.
To face these challenges, the SOUL project aims to develop novel, biodegradable materials with high renewable content, transforming existing plastic products, and developing sustainable end-of-life solutions. SOUL seeks to produce and bring to market innovative bio-based and biodegradable in soil product solutions to contribute to a more sustainable and circular plastic economy.
PERIOD: September 2025 – August 2029
TOTAL BUDGET: 10,014,752 €
PARTNERS
- FUNDACION AITIIP (Coordinator)
- NOVAMONT SPA
- EVOENZYME SL
- AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
- MOSES PRODUCTOS SL
- AMORIM CORK SOLUTIONS, S.A
- Tenax S.p.A.
- SICOR SOCIEDADE INDUSTRIAL DE CORDOARIA SA
- Samco Agricultural Manufacturing Limited
- ASOCIACION ESPAÑOLA PARA EL DESARROLLO Y TRANSFERENCIA TECNOLOGICA EN LA AGRICULTURA Y LA GANADERIA – ASETAGA
- INSTYTUT UPRAWY NAWOZENIA I GLEBOZNAWSTWA, PANSTWOWY INSTYTUT BADAWCZY
- AIMPLAS – ASOCIACION DE INVESTIGACION DE MATERIALES PLASTICOS Y CONEXAS
- NORMEC OWS
- ALMA MATER STUDIORUM – UNIVERSITA DI BOLOGNA
- HOLOSS – HOLISTIC AND ONTOLOGICALSOLUTIONS FOR SUSTAINABILITY, LDA
- RE SOIL FOUNDATION
- EUROPEAN BIOECONOMY BUREAU
Extended Consortium Members:
- NOVAMONT IBERIA S.L. (Associated Entity)
- Bedoukian Research Switzerland Sàrl (Affiliated Partner)
EVOENZYME PARTICIPATION
EVOENZYME will play a significant role in the SOUL project, participating in the production and upscaling of novel enzymes for improved biodegradability on soil. The company’s main focus is on the identification and selection of enzyme variants capable of effectively degrading biobased polyesters in soil applications. To achieve this, we will apply our expertise in enzyme engineering with directed evolution and computational approaches for biodegradation processes. Additionally, our work will extend to enzyme scale-up production and degradation reactions, contributing to the project’s objectives by reducing plastic pollution, improving soil health, and promoting sustainable agriculture and climate action.
SOUL is funded by the Circular Bio-Based Europe Joint Undertaking under the European Union’s Horizon Europe Research and Innovation programme under grant agreement No. 101214822.
Co-funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or Circular Bio-based Europe Joint Undertaking. Neither the European Union nor the granting authority can be held responsible for them.
Latest news
- September 1, 2025
2024 – 2027
RENEWABLE ENERGY
Hydrogenases for large scale deployment of H2 as a circular energy carrier in industrial biotechnology based on enzymatic catalysts
CirculH2
CirculH2 addresses the need for a rapid shift to renewable practices in industrial biotechnology. Focusing on enzyme-based processes, the project introduces robust and scalable hydrogenases, Nature’s catalysts for clean H2 utilization. The goal is to develop highly scalable hydrogenases that selectively drive biotransformations of bio-based materials into chemicals. CirculH2 aims to replace legacy chemical production methods, contributing to the decarbonization of industrial biotechnology while enhancing European competitiveness in sustainable chemical production.
PERIOD: January 2024 – January 2028
TOTAL BUDGET: 5,676,950.00€
PARTNERS
- TU Muenchen (Coordinator)
- EvoEnzyme SL
- TU Delft
- CASCAT GMBH
- Sveuciliste u Zagrebu fakultet kemijskog inzenjerstva i tehnologije
- ACIB GMBH
- ECONUTRI GMBH
- AXXENCE SLOVAKIA SRO
- Astrazeneca AB
- Enzymicals AG
- Sustainable Momentum SL
EVOENZYME PARTICIPATION
EvoEnzyme takes a pivotal role in the CirculH2 project, leading the way in enzyme engineering. Our expertise will be instrumental in optimizing and developing robust hydrogenases, contributing to the project’s goal of harnessing H2 for sustainable industrial biotechnology.
Latest news
- February 12, 2024
2024 – 2027
PLASTIC DEGRADATION
Forging the blades of the future with composite materials with circular, safe and sustainable design
BLADE2CIRC
BLADE2CIRC is a pioneering project focused on bio-based solutions for sustainable wind energy. It explores high-strength biobased carbon fibers and dynamic biobased structural resins, aiming to enhance the lifetime and circularity of wind energy systems. The project introduces technologies such as self-healing coatings, debondable adhesives for recycling, and green solvents with evolved degradative enzymes for fiber recovery. Leveraging insights from previous successful projects, BLADE2CIRC ensures competitive performance through testing and validation.
PERIOD: 2024 – 2027
TOTAL BUDGET: 3,969,228.75€
PARTNERS
- FUNDACION AITIIP (Coordinator)
- EvoEnzyme SL
- University of Limerick
- Agencia estatal consejo superior de investigaciones científicas – CSIC
- Specific Polymers SL
- Centre scientifique & technique del’industrie textile belge asbl
- Instituto tecnológico de Aragón
- EIRECOMPOSITES TEORANTA
- KUNGLIGA TEKNISKA HOEGSKOLAN
- Innovación y consulting tecnologico SL
EVOENZYME PARTICIPATION
EvoEnzyme will play an important role in the BLADE2CIRC project by focusing on enzyme development for the degradation of novel materials. Additionally, our efforts will extend to scaling up the production of enzymes, contributing to the project’s overall objectives in advancing sustainable solutions for the wind energy sector.
Latest news
- July 4, 2025
- June 20, 2025
2020 – 2023
PLASTIC DEGRADATION
Apply lignases to resolve end-of-life issues of thermoset composite plastics
BIZENTE
The BIZENTE project introduces an innovative solution to address the end-of-life challenges of thermoset composites. Through controlled enzymatic biodegradation, it aims to reduce non-biodegradable polymer disposal. This technology targets three thermoset resins and composites not previously considered in the plastics value chain, utilizing evolved oxidoreductases and hydrolytic enzymes for degradation. Once scaled up, the biodegradation products will be repurposed into chemical industry building blocks, contributing to a more sustainable materials management approach.
PERIOD: May 2020 – May 2024
TOTAL BUDGET: 2,974,821.25€
PARTNERS
- FUNDACION AITIIP (Coordinator)
- EvoEnzyme SL
- TU Delft
- ECR Technology A/S
- Specific Polymers SL
- Biosphere SRL
- Universidad de Cádiz – UCA
- Consorcio aeródromo aeropuerto de Teruel
- ACCIONA CONSTRUCCION SA
- AERNNOVA ENGINEERING DIVISION SAU – AED
- AERNNOVA COMPOSITES SA
EVOENZYME PARTICIPATION
EvoEnzyme will take a leading role in the BIZENTE project, focusing on enzyme engineering for the degradation of thermoset materials. Our expertise in this field positions us to optimize degradative enzymes, contributing to the project’s goal of developing sustainable solutions for thermoset composite end-of-life management. In addition, we are actively engaged in collaborative efforts to advance biocatalytic processes for the effective treatment of these materials. This collaboration reflects our commitment to the project’s success and the pursuit of environmentally responsible approaches in materials science.
Latest news
- March 12, 2022
- October 14, 2021
National Projects
2026 – 2029
TEXTILE CIRCULARITY
Investigación en tecnologías disruptivas de reciclaje y ecodiseño para acelerar la circularidad textil y la moda sostenible en la Comunidad de Madrid
CIRTEXCAM
The project “CIRTEXCAM” has been funded through the 2025 Call for Grants aimed at improving public-private cooperation in R&D&I through consortium-based driving-effect projects of the Regional Ministry of Education, Science and Universities of the Community of Madrid, and is co-financed by the European Regional Development Fund (ERDF/FEDER).
The aim of the project is to investigate and validate advanced technological solutions to drive circularity in the textile and clothing sector. This is achieved through eco-design strategies, smart waste sorting, and innovative recycling processes (including mechanical, thermo-mechanical, chemical, thermo-chemical and enzymatic). Additionally, the project will promote digital traceability, the valorization of recycled materials and the development of sustainable textile products with high functional and environmental value.
PERIOD: January 2026 – January 2029
TOTAL BUDGET: 5.045.593,49 €
PARTNERS
- Fábrica Española de Confecciones S.A. (FECSA) (Coordinator)
- Universidad especializada en Diseño, Innovación y Tecnología (UDIT)
- Valoriza Servicios Medioambientales S.A.
- Asociación de Empresas de Confección y Moda de la Comunidad de Madrid (ASECOM)
- EvoEnzyme S.L.
- Global Factor International Consulting
- TREE Technology
- T-NEUTRAL
COLLABORATING ENTITIES
- TECNALIA
- AITEX
- HILATURAS ARNAU
EVOENZYME PARTICIPATION
Within the project, which combines mechanical, chemical, and enzymatic routes to treat mixed textiles, EvoEnzyme will lead the development of the biotechnological route.
The company will research, design and optimize specific enzymatic solutions (based on cellulases, cutinases/PETases and polyamidases) to selectively hydrolyze target components such as cotton, polyester and polyamide. This approach enables the controlled decomposition of the textile matrix, facilitating component separation for high-value recycling and circular valorization.
Latest news
Nothing Found
2025 – 2028
PLASTIC DEGRADATION
Cooperación e Investigación para la Circularidad en la Industria Eólica
CICLO
The project “CICLO” (Expedient number: MIG-20242115) is subsidized by the Center for Technological Development and Innovation (CDTI) and supported by the Ministry of Science, Innovation and Universities. This project has been funded by CDTI through a grant from the “Science and Innovation Missions – Transmissions 2024” Programme.
The aim of the project is to investigate new technological solutions to boost the circular economy in the field of renewable energies, specifically in the recycling and recovery of wind blades and other composite components used in the construction of wind turbines such as nacelles, electrical cabinets, etc. at the end of their life cycle.
CICLO is a consortium formed by 8 companies (ACCIONA, AFESA, INPRE, MENZOLIT, ITSA, PLASTIBOR, OMAR, EVOENZYME) led by ACCIONA, 6 research organizations of which 3 are CSIC institutes (ICTP_CSIC, ICB_CSIC, ICP_CSIC) and 3 technology centers (AITTIP, GAIKER, AITEX) led by GAIKER. With all these actors involved, the necessary value chain is completed to investigate with possibilities of success the recycling and valuation of blades at the end of their life cycle. In addition, in order to facilitate recycling, research will be carried out on alternative materials to the current ones that are more easily recyclable.
PERIOD: January 2025- December 2028
TOTAL BUDGET: 8.602.246,68 €
PARTNERS
CDTI Group
- ACCIONA CONSTRUCCIÓN, S.A.U. (Coordinator)
- AFESA MEDIO AMBIENTE, S.A.
- INDUSTRIAS NAVARRAS DEL PLASTICO REFORZADO, S.L.
- OMAR COATINGS, S.A.
- PLASTIBOR S.L.
- INDUSTRIAL DE TRANSFORMADOS, S.A.
- EVOENZYME SL
- MENZOLIT VITROPLAST SL
State Research Agency (AEI) Group
- CENTRO TECNOLÓGICO GAIKER (Coordinator)
- CSIC-INSTITUTO DE CIENCIA Y TECNOLOGÍA DE POLÍMEROS (ICTP)
- CSIC-INSTITUTO DE CATÁLISIS Y PETROLEOQUÍMICA (ICP)
- CSIC-INSTITUTO DE CARBOQUÍMICA (ICB)
- FUNDACIÓN AITIIP
- ASOCIACIÓN DE INVESTIGACIÓN DE LA INDUSTRIA TEXTIL
EVOENZYME PARTICIPATION
EvoEnzyme is contributing to the circular economy in renewable energy by developing enzymatic solutions for composite material degradation within the CICLO project. The company’s core work is focused on optimizing enzyme effectiveness to break down the complex composites found in wind turbine blades. EvoEnzyme is actively researching methods to enhance enzyme performance and thoroughly analyzing how enzymes interact with resin materials. A significant part of their contribution is the development of scalable and efficient enzyme production methods using microbial fermentation, which is crucial for enabling large-scale composite recycling in the future.
Latest news
- July 4, 2025
- June 20, 2025
2024 – 2027
RENEWABLE ENERGY
HUB de Innovación de Combustibles de Aviación Sostenibles (SAF) de la Comunidad de Madrid
MADRID VUELA SOSTENIBLE
“HUB de Innovación de Combustibles de Aviación Sostenibles (SAF) de la Comunidad de Madrid” is a collaborative consortium from the Community of Madrid led by REPSOL. MADRID VUELA SOSTENIBLE is a project that aims to generate and share knowledge about new technologies that facilitate the recovery of waste for use as raw materials in industrial processes, especially in the production of aviation fuels with a low carbon footprint. The project seeks to promote cooperation among the various actors of the science-technology-business system, with a focus on the participation of small and medium-sized enterprises (SMEs) in large-scale industrial research projects.
PERIOD: January 2024 – January 2027
TOTAL BUDGET: 5,598,185.49 €
PARTNERS
- Repsol SA (Coordinator)
- IMDEA Energy Institute
- EvoEnzyme SL
- Ariema Energía y Medioambiente SL
Advisors:
- Iberia SA
- Técnicas Reunidas SA
- Institute of Catalysis and Petrochemistry ICP-CSIC
EVOENZYME PARTICIPATION
Within the project, EVOENZYME will be responsible for the comprehensive development of advanced enzymatic technologies for lignocellulosic biomass treatments. Specifically, this entails the removal of lignin and the degradation of cellulose into fermentable sugars for the synthesis of biofuels.
Latest news
2020 – 2023
RENEWABLE ENERGY
Hub de Innovación de Economía Circular de la Comunidad de Madrid
Madrid + Circular
Within the HUB, the whole consortium coordinates efforts along the life-cycle of materials and residues: from urban waste management to plastic processing. The technological synergies of the HUB will also be explored in terms of clean hydrogen and biofuels production.
PERIOD: November 2021-November 2023
TOTAL BUDGET: 4,054,482.72€
PARTNERS
- Repsol (Coordinator)
- IMDEA Energy Institute
- EvoEnzyme
- Ariema Energía y Medioambiente
- Seenso Renova
EVOENZYME PARTICIPATION
During the project, EvoEnzyme will be focused in developing new enzymatic technologies for the valorization of different residues within the integration in bio-refinery processes:
- It will be explored the design of enzymatic systems for the preparation of precursors of advanced materials based on recovered molecules from lingocellulosic waste.
- The company will put special focus on developing technologies related to bioplastic circularity (synthesis and degradation) with the action of engineered enzymes.
- EvoEnzyme will have the goal of setting up enzymatic platforms for the study and valorization of the most interesting fractions of pyrolytic processes from different waste materials.
Latest news
- October 25, 2021
2019 – 2022
EVOCHIMERA
SUSTAINABLE CHEMISTRY
Synthetic chemistry using fusion chimeras engineered by directed and computational evolution
EVOCHIMERA
PERIOD: January 2017 – January 2020
PARTNERS
- Institute of Catalysis and Petrochemistry ICP-CSIC (Coordinator)
- Physico-chemistry Institute Blas Cabrera
- EvoEnzyme SL
EVOENZYME PARTICIPATION
EvoEnzyme actively supports the production processes of the chimeric enzymes in bioreactors. Leveraging expertise in enzyme bioprocessing, the company works in the advance for sustainable and industrial-scale applications.
Grants
EVOFARMA – RIS3 CAM
Línea 1. 2020-2021
CONTRATOS TORRES QUEVEDO
PTQ 2020 – 2023
SNEO-20201094
2021 – 2022
NEOTEC
«ENZIMAS EVOLUCIONADAS: SOLUCIONES A MEDIDA PARA EL SECTOR FARMACÉUTICO, DE PLÁSTICOS, QUÍMICO, ENERGÉTICO Y MEDIOAMBIENTAL»
The NEOTEC program, run by CDTI, is designed to support the establishment and growth of technology-based companies. The most important aspect in proposals supported by the NEOTEC program is a business strategy based on technology development with focus on creating its own research, development, and innovation lines. In this context, EvoEnzyme offers a unique business plan and technology that utilizes enzymatic applications across various sectors. The company provides services of directed evolution and enzyme sales, initially focused on the pharmaceutical, plastic degradation, and bioplastic sectors, with the goal of later expanding into the energy and environmental sectors interested in the development of sustainable alternatives in the production of biofuels and the chemical sector.
PARTNERS
- EvoEnzyme
PERIOD: January 2021 – December 2022
REF: SNEO-20201094
EVOENZYME PARTICIPATION
During the NEOTEC program, several key considerations are taken into account:
- To develop a comprehensive commercial exploitation plan for the project, bringing the product or service to market and achieving commercial viability. This plan should encompass product catalogs, target clients, and relevant sectors.
- Revision of the main technology to achieve innovation developments. Increasing the impact of the company based on market research.
- To evaluate the management capacity of the entrepreneurial team involved in the project’s development to ensure its success.
- To pay special attention to thoroughly evaluating the social, economic, and environmental impact of the project to ensure its sustainability and positive impact on society.
CONTRATOS TORRES QUEVEDO
PTQ 2021 – 2024
DOCTORES INDUSTRIALES
2025 – 2028
Acceleration & Scale Up Programs
2018
2020-2021
2021-2022
2022-2023
Jump Startup Women
2023
SILO acelera bio
2024
Technological platforms
