We Are Evolvers

DIRECTED EVOLUTION: BRINGING THE CYCLE OF LIFE TO THE LABORATORY BENCH

Directed evolution is an engineering strategy used to customize enzymes for different purposes, ranging from industrial and environmental applications to drug discovery. Mimicking the processes of natural evolution in the laboratory, this method was pioneered by Prof. Frances H. Arnold, for which she was awarded the Nobel Prize in Chemistry 2018. Indeed, it is considered the most revolutionary protein engineering method known to date.

In this procedure, genetic diversity is first created by random mutagenesis and/or the recombination of parental genes. Once the mutant libraries are expressed in a suitable host organism, they can be screened  in high-throughput platforms to search for specific biochemical traits, for example: activity under extreme pH or temperatures, changes in substrate preferences, heterologous expression, tolerance in the presence of strong inhibitors, etc. In this way, selective pressure can be strictly controlled by the researcher until the desired properties are attained.

We can help you to develop your directed evolution platforms as well as to design enzymes for a variety of applications, from bioremediation to novel green processes.