Research projects
We are involved in publicly funded projects
R&D Projects
European Projects
EIC Pathfinders
2023 – 2027
MEDICAL DEVICES
A Paradigm Shift in Health Monitoring with Electrospun Enzymatic Neomaterials
Woundsens
The WOUNDSENS project addresses the global healthcare challenge posed by chronic non-healing wounds, affecting up to 2% of the world population. Recognizing the lack of smart bandages in the market, the project aims to pioneer a novel generation of wearable biosensors. WOUNDSENS integrates sensor elements directly into wound dressing material, enhancing comfort and operability. This breakthrough technology utilizes hollow fibers with radial bio-signaling based on engineered enzymes. The project encompasses advances in conductive materials, electrospinning methodologies, and enzyme engineering to create a sensitive and reliable continuous wound control and monitoring system. WOUNDSENS represents a paradigm shift in smart wound dressings, offering a new concept to improve the quality of life for millions of people while addressing the economic impact on healthcare.
PERIOD: November 2023 – November 2027
TOTAL BUDGET: 2,934,318.75€
PARTNERS
- EvoEnzyme SL (Coordinator)
- Naturwissenschaftliches und medizinisches institut an der universitaet Tuebingen
- Universite de Lorraine
EVOENZYME PARTICIPATION
EvoEnzyme functions as the Coordinator of the WOUNDSENS project. Additionally, our role involves working on enzyme engineering for sensor manufacturing through directed evolution and computational methods.
2024-2028
SUSTAINABLE CHEMISTRY
Tungsten biocatalysis – heavy metal enzymes for sustainable industrial biocatalysis
W-BioCat
The W-BioCat project addresses the need for a sustainable chemical industry in Europe through groundbreaking enzyme technology. By unlocking the potential of tungsten-containing enzymes (W-enzymes), the project aims to revolutionize chemical manufacturing. Focusing on overcoming the bottleneck of W-cofactor biosynthesis in E. coli, the project utilizes advanced computational enzyme design to create a new biosynthesis pathway. This innovation will enable the production of W-enzymes at an industrial scale, paving the way for their application in catalyzing novel chemical reactions, including biocatalytic CO2 reduction and Birch reduction of aromatic compounds. W-BioCat’s proof of concept involves a hydrogen-driven process to convert plant-derived oleic acid to oleyl oleate, a key ingredient in cosmetic products.
PERIOD: February 2024 – February 2028
TOTAL BUDGET: 2,430,574.75€
PARTNERS
- TU Delft (Coordinator)
- EvoEnzyme SL
- Weizmann institute of science
- Consorzio interuniversitario risonanze magnetiche di metallo proteine
EVOENZYME PARTICIPATION
EvoEnzyme will play a crucial role in the W-BioCat project, focusing on protein engineering through ancestral reconstruction, resurrection, and directed evolution of W-enzymes. Our expertise in these advanced techniques will contribute to the successful development and optimization of novel W-enzyme systems.
Other European projects
2024 – 2027
RENEWABLE ENERGY
Hydrogenases for large scale deployment of H2 as a circular energy carrier in industrial biotechnology based on enzymatic catalysts
CirculH2
CirculH2 addresses the need for a rapid shift to renewable practices in industrial biotechnology. Focusing on enzyme-based processes, the project introduces robust and scalable hydrogenases, Nature’s catalysts for clean H2 utilization. The goal is to develop highly scalable hydrogenases that selectively drive biotransformations of bio-based materials into chemicals. CirculH2 aims to replace legacy chemical production methods, contributing to the decarbonization of industrial biotechnology while enhancing European competitiveness in sustainable chemical production.
PERIOD: January 2024 – January 2028
TOTAL BUDGET: 5,676,950.00€
PARTNERS
- TU Muenchen (Coordinator)
- EvoEnzyme SL
- TU Delft
- CASCAT GMBH
- Sveuciliste u Zagrebu fakultet kemijskog inzenjerstva i tehnologije
- ACIB GMBH
- ECONUTRI GMBH
- AXXENCE SLOVAKIA SRO
- Astrazeneca AB
- Enzymicals AG
- Sustainable Momentum SL
EVOENZYME PARTICIPATION
EvoEnzyme takes a pivotal role in the CirculH2 project, leading the way in enzyme engineering. Our expertise will be instrumental in optimizing and developing robust hydrogenases, contributing to the project’s goal of harnessing H2 for sustainable industrial biotechnology.
2024 – 2027
PLASTIC DEGRADATION
Forging the blades of the future with composite materials with circular, safe and sustainable design
BLADE2CIRC
BLADE2CIRC is a pioneering project focused on bio-based solutions for sustainable wind energy. It explores high-strength biobased carbon fibers and dynamic biobased structural resins, aiming to enhance the lifetime and circularity of wind energy systems. The project introduces technologies such as self-healing coatings, debondable adhesives for recycling, and green solvents with evolved degradative enzymes for fiber recovery. Leveraging insights from previous successful projects, BLADE2CIRC ensures competitive performance through testing and validation.
PERIOD: 2024 - 2027
TOTAL BUDGET: 3,969,228.75€
PARTNERS
- FUNDACION AITIIP (Coordinator)
- EvoEnzyme SL
- University of Limerick
- Agencia estatal consejo superior de investigaciones científicas – CSIC
- Specific Polymers SL
- Centre scientifique & technique del'industrie textile belge asbl
- Instituto tecnológico de Aragón
- EIRECOMPOSITES TEORANTA
- KUNGLIGA TEKNISKA HOEGSKOLAN
- Innovación y consulting tecnologico SL
EVOENZYME PARTICIPATION
EvoEnzyme will play an important role in the BLADE2CIRC project by focusing on enzyme development for the degradation of novel materials. Additionally, our efforts will extend to scaling up the production of enzymes, contributing to the project's overall objectives in advancing sustainable solutions for the wind energy sector.
2020 – 2023
PLASTIC DEGRADATION
Apply lignases to resolve end-of-life issues of thermoset composite plastics
BIZENTE
The BIZENTE project introduces an innovative solution to address the end-of-life challenges of thermoset composites. Through controlled enzymatic biodegradation, it aims to reduce non-biodegradable polymer disposal. This technology targets three thermoset resins and composites not previously considered in the plastics value chain, utilizing evolved oxidoreductases and hydrolytic enzymes for degradation. Once scaled up, the biodegradation products will be repurposed into chemical industry building blocks, contributing to a more sustainable materials management approach.
PERIOD: May 2020 - May 2024
TOTAL BUDGET: 2,974,821.25€
PARTNERS
- FUNDACION AITIIP (Coordinator)
- EvoEnzyme SL
- TU Delft
- ECR Technology A/S
- Specific Polymers SL
- Biosphere SRL
- Universidad de Cádiz – UCA
- Consorcio aeródromo aeropuerto de Teruel
- ACCIONA CONSTRUCCION SA
- AERNNOVA ENGINEERING DIVISION SAU – AED
- AERNNOVA COMPOSITES SA
EVOENZYME PARTICIPATION
EvoEnzyme will take a leading role in the BIZENTE project, focusing on enzyme engineering for the degradation of thermoset materials. Our expertise in this field positions us to optimize degradative enzymes, contributing to the project's goal of developing sustainable solutions for thermoset composite end-of-life management. In addition, we are actively engaged in collaborative efforts to advance biocatalytic processes for the effective treatment of these materials. This collaboration reflects our commitment to the project's success and the pursuit of environmentally responsible approaches in materials science.
National Projects
2020 – 2023
RENEWABLE ENERGY
Hub de Innovación de Economía Circular de la Comunidad de Madrid
Madrid + Circular
Within the HUB, the whole consortium coordinates efforts along the life-cycle of materials and residues: from urban waste management to plastic processing. The technological synergies of the HUB will also be explored in terms of clean hydrogen and biofuels production.
PERIOD: November 2021-November 2023
TOTAL BUDGET: 4,054,482.72€
PARTNERS
- Repsol (Coordinator)
- IMDEA Energy Institute
- EvoEnzyme
- Ariema Energía y Medioambiente
- Seenso Renova
EVOENZYME PARTICIPATION
During the project, EvoEnzyme will be focused in developing new enzymatic technologies for the valorization of different residues within the integration in bio-refinery processes:
- It will be explored the design of enzymatic systems for the preparation of precursors of advanced materials based on recovered molecules from lingocellulosic waste.
- The company will put special focus on developing technologies related to bioplastic circularity (synthesis and degradation) with the action of engineered enzymes.
- EvoEnzyme will have the goal of setting up enzymatic platforms for the study and valorization of the most interesting fractions of pyrolytic processes from different waste materials.
2024 – 2027
RENEWABLE ENERGY
HUB de Innovación de Combustibles de Aviación Sostenibles (SAF) de la Comunidad de Madrid
MADRID VUELA SOSTENIBLE
"HUB de Innovación de Combustibles de Aviación Sostenibles (SAF) de la Comunidad de Madrid" is a collaborative consortium from the Community of Madrid led by REPSOL. MADRID VUELA SOSTENIBLE is a project that aims to generate and share knowledge about new technologies that facilitate the recovery of waste for use as raw materials in industrial processes, especially in the production of aviation fuels with a low carbon footprint. The project seeks to promote cooperation among the various actors of the science-technology-business system, with a focus on the participation of small and medium-sized enterprises (SMEs) in large-scale industrial research projects.
PERIOD: January 2024 – January 2028
TOTAL BUDGET: 5,598,185.49 €
PARTNERS
- Repsol SA (Coordinator)
- IMDEA Energy Institute
- EvoEnzyme SL
- Ariema Energía y Medioambiente SL
Advisors:
- Iberia SA
- Técnicas Reunidas SA
- Institute of Catalysis and Petrochemistry ICP-CSIC
EVOENZYME PARTICIPATION
Within the project, EVOENZYME will be responsible for the comprehensive development of advanced enzymatic technologies for lignocellulosic biomass treatments. Specifically, this entails the removal of lignin and the degradation of cellulose into fermentable sugars for the synthesis of biofuels.
2019 – 2022
EVOCHIMERA
SUSTAINABLE CHEMISTRY
Synthetic chemistry using fusion chimeras engineered by directed and computational evolution
EVOCHIMERA
PERIOD: January 2017 - January 2020
PARTNERS
- Institute of Catalysis and Petrochemistry ICP-CSIC (Coordinator)
- Physico-chemistry Institute Blas Cabrera
- EvoEnzyme SL
EVOENZYME PARTICIPATION
EvoEnzyme actively supports the production processes of the chimeric enzymes in bioreactors. Leveraging expertise in enzyme bioprocessing, the company works in the advance for sustainable and industrial-scale applications.
Grants
2020 - 2021
EVOFARMA - RIS3 CAM
RIS 3 Línea 1.
EvoEnzyme.
2020 - 2023
CONTRATOS TORRES QUEVEDO
PTQ 2020 - 2023
2021 - 2022
SNEO-20201094
NEOTEC
«ENZIMAS EVOLUCIONADAS: SOLUCIONES A MEDIDA PARA EL SECTOR FARMACÉUTICO, DE PLÁSTICOS, QUÍMICO, ENERGÉTICO Y MEDIOAMBIENTAL»
The NEOTEC program, run by CDTI, is designed to support the establishment and growth of technology-based companies. The most important aspect in proposals supported by the NEOTEC program is a business strategy based on technology development with focus on creating its own research, development, and innovation lines. In this context, EvoEnzyme offers a unique business plan and technology that utilizes enzymatic applications across various sectors. The company provides services of directed evolution and enzyme sales, initially focused on the pharmaceutical, plastic degradation, and bioplastic sectors, with the goal of later expanding into the energy and environmental sectors interested in the development of sustainable alternatives in the production of biofuels and the chemical sector.
PARTNERS
- EvoEnzyme
PERIOD: January 2021 - December 2022
REF: SNEO-20201094
EVOENZYME PARTICIPATION
During the NEOTEC program, several key considerations are taken into account:
- To develop a comprehensive commercial exploitation plan for the project, bringing the product or service to market and achieving commercial viability. This plan should encompass product catalogs, target clients, and relevant sectors.
- Revision of the main technology to achieve innovation developments. Increasing the impact of the company based on market research.
- To evaluate the management capacity of the entrepreneurial team involved in the project's development to ensure its success.
- To pay special attention to thoroughly evaluating the social, economic, and environmental impact of the project to ensure its sustainability and positive impact on society.
2021 - 2024
CONTRATOS TORRES QUEVEDO
PTQ 2021 - 2024
Acceleration & Scale Up Programs
2018
2020-2021
2021-2022
2022-2023
Jump Startup Women
2023
SILO acelera bio
2024
Technological platforms
