RESEARCH
From renewable energy
to healthcare.
We are involved in publicly funded research projects — from EIC Pathfinder and Horizon Europe grants to national and regional programs — spanning medical devices, sustainable chemistry, plastic degradation, renewable energy, textile circularity and synthetic biology.
14
active projects & grants
7
completed projects & grants
~€60M
combined budget of projects & grants
6
research areas
R&D Projects
Publicly funded research
Filter by research area. Click a project to see partners, budget and EvoEnzyme’s role.
EIC Pathfinders
A paradigm shift in health monitoring with electrospun enzymatic neomaterials — smart bandages for chronic wound monitoring.
Total budget: €2,934,319 · EvoEnzyme is Coordinator
WoundSens addresses chronic non-healing wounds, affecting up to 2% of the world population, by pioneering wearable biosensors integrated directly into wound dressings — hollow fibers with radial bio-signaling based on engineered enzymes.
Partners
- EvoEnzyme SL (Coordinator)
- NMI Naturwissenschaftliches und medizinisches Institut, Tübingen
- Université de Lorraine
EvoEnzyme’s role
Coordinator of the project; enzyme engineering for sensor manufacturing through directed evolution and computational methods.
Coordinator of the project; enzyme engineering for sensor manufacturing through directed evolution and computational methods.
EvoEnzyme visits the NMI for WoundSens consortium meeting — Apr 2026
WoundSens YouTube channel →
Tungsten biocatalysis — heavy metal enzymes for sustainable industrial biocatalysis.
Total budget: €2,430,575 · Coordinator: TU Delft
W-BioCat unlocks tungsten-containing enzymes (W-enzymes) via computational design to overcome the W-cofactor biosynthesis bottleneck in E. coli, enabling applications like biocatalytic CO₂ reduction and cosmetic ingredient synthesis.
Partners
- TU Delft (Coordinator)
- EvoEnzyme SL
- Weizmann Institute of Science
- CIRMMP (Italy)
- Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences
EvoEnzyme’s role
Protein engineering through ancestral reconstruction, resurrection and directed evolution of W-enzymes.
EvoEnzyme at the W-BioCat meeting in Kraków — Apr 2026
Other European Projects
RELEASAFE
Bio-based and biodegradable controlled-release fertilisers for safe and sustainable agriculture.
Total budget: €3,668,790 · Coordinator: Fundación AITIIP
Funded under Horizon Europe, Circular Bio-based Europe Joint Undertaking (call HORIZON-JU-CBE-2025-RIA-02). Grant requested: €3,484,761.
Partners
- Fundación AITIIP (ES)
- RB TS BV (NL)
- LANDLAB SRL (IT)
- EvoEnzyme SL (ES)
- HOLOSS – Holistic and Ontological Solutions for Sustainability, Lda (PT)
- Acondicionamiento Tarrasense Associacion (ES)
- Van Iperen International B.V. (NL)
- Fundación CENER (ES)
- MTU Australo Alpha Lab (EE)
EvoEnzyme’s role
EvoEnzyme’s share: €350,175 total eligible costs (9.54%), €328,114 grant requested (9.42%).
A postdoctoral training programme recruiting the next generation of European leaders in synthetic cell research.
EU contribution: €6,768,000 (Marie Skłodowska-Curie Actions Cofund Postdoctoral programme. Coordinator: Max Planck Society (MPG)
An MSCA Cofund postdoctoral programme led by the Max Planck Society, coordinated through the Max Planck Institute of Biochemistry and the Max Planck Institute for Terrestrial Microbiology, recruiting 40 postdoctoral researchers into four thematic areas: Metabolism & Energy, Division & Replication, Information Processing & Evolution, and Enabling Technologies. 22 research organisations across Europe take part as Implementing Partners hosting the fellows, alongside Associated Partners from the SynBioEU network and private industry, as part of the pan-European SynCellEU initiative.
Partners (selection)
- Max Planck Society, MPG (Coordinator)
- EvoEnzyme SL (associated partner)
- Merck KGaA
- BASF SE
- Repsol SA
- Carl Zeiss AG
- Leica Microsystems CMS GmbH
- VTT (Finland)
- and other partners — see CORDIS for the full list
EvoEnzyme’s role
Associated partner; confirmed as a host for postdoctoral researchers’ training placements within the programme.
CHIHIRO
Circular valorisation of guayule bagasse and resin for high-performance bio-based rubber materials.
Total budget: €3,687,196 · Coordinator: Moses Productos S.L.
Europe’s first sustainable biorefinery for guayule, a resilient crop offering a local alternative to fossil-based rubber and imported latex, using engineered yeast to produce polyisoprene and green chemistry for bio-based elastomers.
Partners
- Moses Productos S.L. (Coordinator)
- Guatecs
- Celabor SCRL
- EvoEnzyme S.L.
- Universitat Rovira i Virgili
- Deutsches Institut für Kautschuktechnologie eV
- HOLOSS Lda
- Polymeris
- Miniland S.A.
EvoEnzyme’s role
Biomanufacturing strategies for high-molecular-weight polyisoprene production from bagasse-derived sugars; enzymatic systems to convert guayule bagasse cellulose into glucose.
EvoEnzyme at the CHIHIRO kick-off meeting — May 2026
Machine learning for integrated multi-parametric enzyme and bioprocess design.
EU contribution: €4,470,728 (Marie Skłodowska-Curie Doctoral Network — EvoEnzyme participates as an associated partner, not a funded beneficiary) · Coordinator: Technical University of Denmark (DTU)
A Marie Skłodowska-Curie Actions Doctoral Network under Horizon Europe, training researchers in machine-learning-guided enzyme and bioprocess design. 12 beneficiaries and 15 associated partners across Denmark, Spain, Italy, the Netherlands, Croatia, Austria, Czechia, Germany and France.
Partners (selection)
- Technical University of Denmark, DTU (Coordinator)
- EvoEnzyme SL (associated partner)
- CSIC
- Universidad de Girona
- Universidad Autónoma de Madrid
- TU Delft
- Novozymes
- AstraZeneca
- PEACCEL
- Innophore
- Exazyme
- EnginZyme
- and other partners — see CORDIS for the full list
EvoEnzyme’s role
Associated partner providing hands-on training and secondments for doctoral researchers in the network.
Bio-based, soil-biodegradable products for a more sustainable and circular plastic economy.
Total budget: €10,014,752 · Coordinator: Fundación AITIIP
SOUL tackles soil plastic pollution and microplastic accumulation by developing biodegradable, renewable-content materials with sustainable end-of-life solutions.
Partners (17)
- Fundación AITIIP (Coordinator)
- Novamont SpA
- EvoEnzyme SL
- CSIC
- Moses Productos SL
- Amorim Cork Solutions S.A.
- Tenax S.p.A.
- Sicor SA
- Samco Agricultural Manufacturing Ltd
- ASETAGA
- IUNG-PIB (Poland)
- AIMPLAS
- Normec OWS
- Università di Bologna
- HOLOSS Lda
- RE-Soil Foundation
- European Bioeconomy Bureau
EvoEnzyme’s role
Identification and selection of enzyme variants that degrade bio-based polyesters in soil, plus scale-up production of these enzymes.
EvoEnzyme at the SOUL kick-off meeting — Sep 2025
Circular, safe and sustainable composite materials — forging the wind turbine blades of the future.
Total budget: €3,969,229 · Coordinator: Fundación AITIIP
Explores biobased carbon fibers, self-healing coatings, debondable adhesives, and green solvents with evolved degradative enzymes for fiber recovery in wind energy systems.
Partners
- Fundación AITIIP (Coordinator)
- EvoEnzyme SL
- University of Limerick
- CSIC
- Specific Polymers SL
- Centexbel
- Instituto Tecnológico de Aragón
- EireComposites Teoranta
- KTH Royal Institute of Technology
- Innovación y Consulting Tecnológico SL
EvoEnzyme’s role
Enzyme development for degrading novel materials, and scale-up of enzyme production.
EvoEnzyme at the BLADE2CIRC meeting in Montpellier — Dec 2025
Hydrogenases for large-scale deployment of H₂ as a circular energy carrier in industrial biotechnology.
Total budget: €5,676,950 · Coordinator: TU München
Develops robust, scalable hydrogenases — nature’s catalysts for clean H₂ utilization — to replace legacy chemical production methods and decarbonize industrial biotechnology.
Partners
- TU München (Coordinator)
- EvoEnzyme SL
- TU Delft
- CASCAT GmbH
- University of Zagreb
- ACIB GmbH
- Econutri GmbH
- Axxence Slovakia s.r.o.
- AstraZeneca AB
- Enzymicals AG
- Sustainable Momentum SL
EvoEnzyme’s role
Leads enzyme engineering, optimizing and developing robust hydrogenases.
EvoEnzyme at the CirculH2 meeting in Graz — Jun 2025
Enzymatic lignases to resolve end-of-life issues of thermoset composite plastics.
Total budget: €3,185,071 · Coordinator: Fundación AITIIP
Controlled enzymatic biodegradation targeting three thermoset resins/composites not previously part of the plastics value chain, repurposing degradation products as chemical industry building blocks.
Partners
- Fundación AITIIP (Coordinator)
- EvoEnzyme SL
- TU Delft
- ECR Technology A/S
- Specific Polymers SL
- Biosphere SRL
- Universidad de Cádiz
- Consorcio Aeródromo Aeropuerto de Teruel
- Acciona Construcción SA
- Aernnova Engineering Division SAU
- Aernnova Composites SA
EvoEnzyme’s role
Led enzyme engineering for thermoset material degradation.
National Projects
CIRTEXCAM
Disruptive recycling and eco-design technologies to accelerate textile circularity in the Community of Madrid.
Total budget: €5,045,593 · Coordinator: FECSA
Funded by the Community of Madrid’s 2025 public-private R&D&I cooperation call, co-financed by the ERDF/FEDER. Combines eco-design, smart waste sorting and mechanical, thermo-mechanical, chemical and enzymatic recycling routes.
Partners
- FECSA (Coordinator)
- UDIT
- Valoriza Servicios Medioambientales S.A.
- ASECOM
- EvoEnzyme S.L.
- Global Factor International Consulting
- TREE Technology
- T-Neutral
EvoEnzyme’s role
Leads the biotechnological route: enzymatic solutions (cellulases, cutinases/PETases, polyamidases) to selectively hydrolyze cotton, polyester and polyamide for high-value recycling.
EvoEnzyme at the CIRTEXCAM kick-off meeting — Jan 2026
CICLO
Cooperation and research for circularity in the wind energy industry — recycling wind turbine blades.
Total budget: €8,602,247 · Coordinator: Acciona Construcción
Funded by CDTI (Ministry of Science, Innovation and Universities) under the “Science and Innovation Missions – Transmisiones 2024” programme. Consortium of 8 companies and 6 research organizations (incl. 3 CSIC institutes) researching recycling of wind blades and other composite turbine components.
Partners
- Acciona Construcción S.A.U. (Coordinator)
- AFESA Medio Ambiente S.A.
- Industrias Navarras del Plástico Reforzado
- Omar Coatings S.A.
- Plastibor S.L.
- Industrial de Transformados S.A.
- EvoEnzyme SL
- Menzolit Vitroplast SL
- Centro Tecnológico GAIKER
- CSIC (ICTP, ICP, ICB institutes)
- Fundación AITIIP
- AITEX
EvoEnzyme’s role
Enzymatic solutions for composite material degradation, optimizing enzyme performance against resin materials, and scalable enzyme production via microbial fermentation.
EvoEnzyme at the 2nd CICLO consortium meeting — Oct 2025
Innovation Hub for Sustainable Aviation Fuels (SAF) of the Community of Madrid.
Total budget: €5,598,185 · Coordinator: Repsol
Generates and shares knowledge on technologies that recover waste as raw material for industrial processes, with a focus on low-carbon aviation fuels, promoting SME participation in large-scale research.
Partners
- Repsol SA (Coordinator)
- IMDEA Energy Institute
- EvoEnzyme SL
- Ariema Energía y Medioambiente SL
Advisors
- Iberia SA
- Técnicas Reunidas SA
- ICP-CSIC
EvoEnzyme’s role
Development of enzymatic technologies for lignocellulosic biomass treatment: lignin removal and cellulose degradation into fermentable sugars for biofuel synthesis.
EvoEnzyme at Innovation Day with Madrid Vuela Sostenible — Feb 2026
MADRID + Circular
Circular Economy Innovation Hub of the Community of Madrid.
Total budget: €4,054,483 · Coordinator: Repsol
Developed Circular Economy frameworks for residues — valorized materials and fuels with a focus on renewable energies, coordinating efforts from urban waste management to plastic processing.
Partners
- Repsol (Coordinator)
- IMDEA Energy Institute
- EvoEnzyme
- Ariema Energía y Medioambiente
- Seenso Renova
EvoEnzyme’s role
Enzymatic systems for advanced-material precursors from lignocellulosic waste; bioplastic circularity (synthesis and degradation); enzymatic platforms for valorizing pyrolytic waste fractions.
EVOCHIMERA
Synthetic chemistry using fusion chimeras engineered by directed and computational evolution.
Total budget: €805,200 · Coordinator: Miguel Alcalde’s group, ICP-CSIC
Designed novel chimeric peroxygenase enzymes through laboratory evolution for self-sufficient, sustainable oxygen insertion across synthetic reactions, combining directed molecular evolution with atomic and computational studies. Funded under the Community of Madrid’s Synergic R&D Projects programme.
Partners
- Miguel Alcalde’s group, Institute of Catalysis and Petrochemistry (ICP-CSIC) — Coordinator
- EvoEnzyme (spin-off of the group)
- Julia Sanz’s group, Instituto de Química Física Rocasolano (IQFR-CSIC)
EvoEnzyme’s role
Supported production processes of the chimeric enzymes in bioreactors.
grants
National & regional funding
Doctorados Industriales
Comunidad de Madrid
Jul 2026 – Jun 2029
Doctorados Industriales
Jun 2025 – May 2028
Contratos Torres Quevedo
PTQ · Nov 2021 – Nov 2024
NEOTEC
SNEO-20201094 · 2021–2022
“Evolved enzymes: tailored solutions for the pharmaceutical, plastics, chemical, energy and environmental sectors.” Run by CDTI to support technology-based companies with an R&D-driven business strategy. EvoEnzyme’s proposal centered on enzymatic applications and directed evolution services, initially for pharma, plastic degradation and bioplastics, expanding to energy and environmental sectors.
Period
January 2021 – December 2022 · Ref. SNEO-20201094
Contratos Torres Quevedo
PTQ · Nov 2020 – Nov 2023
EVOFARMA – RIS3 CAM
Line 1 · Feb 2020 – Ene 2021
Acceleration & Scale-Up Programs
Building the company
HealthStart Madrid
2018
Fundación para el Conocimiento madri+d
Fundación Repsol — Fondo de Emprendedores
Oct 2020 – Sep 2021
CatapullUp
2021–2022
Promoted by Fundación Parque Científico de Madrid · supported by Madrid Innovation
Enterprise Europe Network
2022–2023
Jump Startup Women
2023
Entrepreneur Futures Network (EFN) · ESADE–Ramon Llull University Entrepreneurship Institute (EEI) · US Mission Spain & Andorra
SILO Acelera Bio
2024
Funded by the EU (NextGenerationEU) · Plan de Recuperación, Transformación y Resiliencia · EOI · Ministerio de Industria, Comercio y Turismo · sector: biotecnología
Technological Platforms
Where we’re part of the ecosystem
Interested in collaborating
on a research project?
We’re always open to new consortia and public-private partnerships in enzyme engineering. Get in touch to discuss a potential collaboration.