Drug Development

Eco Friendly alternatives

Plastic degradation

Environmental Decontamination

FUNGAL UNSPECIFIC PEROXYGENASES (UPOs)

Peroxygenases perform with high selective complex C-H oxyfunctionalizations triggered simply by hydrogen peroxide. The broad portfolio of reactions performed by UPOs along with their minor requirements place them in a unique position to approach the most innovative chemical rections.

EvoEnzyme has its own collection of evolved peroxygenases and mutant libraries ( WO/2017/081355) to assist to the pharma and chemical industries.

Want to learn more? See some of our recent publications: Gomez de Santos et al. 2018. ACS Catal 8: 4789-4799 ( https://doi.org/10.1021/acscatal.8b01004); Ramirez-Escudero et al. 2018. ACS Chem. Biol. 13: 3259-3268 (https://doi.org/10.1021/acschembio.8b00500); Martin-Diaz et al. 2018. Appl. Environ. Microb. 84: e00808-18 (https://doi.org/10.1128/AEM.00808-18);  Molina-Espeja et al. 2016. ChemBioChem 17: 341-349 (http://doi.org/10.1002/cbic.201500493); Molina-Espeja et al. 2014. Appl. Environ. Microb. 80: 3496-3507 (http://dx.doi.org/10.1128/AEM.00490-14)

Our evolved UPOs can help the pharma sector for the production of human drug metabolites (Gomez de Santos et al. 2018. ACS Catal 8: 4789-4799. https://doi.org/10.1021/acscatal.8b01004; Gomez de Santos et al. 2019. Tetrahedron 75: 1827-1831. https://doi.org/10.1016/j.tet.2019.02.013).

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