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Drug Development
Drug Development
Eco Friendly alternatives
Eco Friendly alternatives
Plastic degradation
Plastic degradation
Environmental Decontamination
Environmental Decontamination

FUNGAL UNSPECIFIC PEROXYGENASES (UPOs)

Peroxygenases are enzymes that perform complex C-H oxyfunctionalizations with a high degree of selectivity, simply triggered by hydrogen peroxide. The broad portfolio of reactions performed by UPOs, along with their less demanding requirements, place these enzymes in a unique position to drive a variety of particularly innovative chemical reactions.

EvoEnzyme has its own collection of evolved peroxygenases and mutant libraries WO/2017/081355 that can be put to use in the pharmaceutical and chemical industries.

To learn more?, see some of our publications: Gomez de Santos et al. 2018. ACS Catal 8: 4789-4799 https://doi.org/10.1021/acscatal.8b01004; Ramirez-Escudero et al. 2018. ACS Chem. Biol. 13: 3259-3268 https://doi.org/10.1021/acschembio.8b00500; Martin-Diaz et al. 2018. Appl. Environ. Microb. 84: e00808-18 https://doi.org/10.1128/AEM.00808-18: Molina-Espeja et al. 2016. ChemBioChem 17: 341-349 ; Molina-Espeja et al. 2014. Appl. Environ. Microb. 80: 3496-3507 http://dx.doi.org/10.1128/AEM.00490-14.

Our evolved UPOs can help the pharma sector for the production of human drug metabolites. Gomez de Santos et al. 2018. ACS Catal 8: 4789-4799. https://doi.org/10.1021/acscatal.8b01004; Gomez de Santos et al. 2019. Tetrahedron 75: 1827-1831. https://doi.org/10.1016/j.tet.2019.02.013.

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LACCASES

VERSATILE PEROXIDASES

ARYL ALCOHOL OXIDASES